Protecting Your CRISPR Assay from RNAse Contamination

The Invisible Enemy

In CRISPR-Cas12/13 diagnostics, RNA reporters are susceptible to rapid degradation by ubiquitous RNAses, leading to false positives (premature cleavage).

Buffer Additives

Incorporating RNAse inhibitors is standard. However, the lateral flow strip itself must be RNAse-free. Due Bio manufacturing lines are ISO-certified and strictly controlled for nuclease contamination.